Summarily, we gave a detailed explanation that lncRNA NEAT1/miR-338-3p refrained cell growth, migration and invasion but expedited apoptosis by modulating CREBRF in AML, manifesting that the NEAT1 exerted the suppression of AML progression by miR-338-3p/CREBRF. The gene discussed is CREBRF; the disease is acute myeloid leukemia.