CDKN3 and chronic liver failure: Xu et al. proposed that NEAT1 could mitigate the acute-on-chronic liver failure by blocking the TRAF6-meidated inflammatory response [31], and Zhang et al. claimed that the oxidative stress-induced vascular endothelial cell injury was suppressed by NEAT1 through the activation of the miR-181d-5p/CDKN3 axis [32].