MAPT and behavioral variant of frontotemporal dementia: The estimated brain concentration of hydromethylthionine required for pharmacological activity (0.02–0.06μM) [49] is consistent with its activity as an inhibitor of both tau [27] and TDP-43 [65] aggregation [34] in vitro, and with the doses required for activity in a tau transgenic mouse model of bvFTD [31].