PPARGC1A and type 2 diabetes mellitus: In diabetic heart, earlier studies reported that hypoadiponectinemia impaired AMPK‐PGC‐1α signalling64; more recently, in a model for type 2 diabetes (a high glucose/high‐fat medium) adiponectin was found to partial rescue mitochondrial biogenesis in cardiomyocytes, via PGC‐1α‐mediated signalling.36