PPARGC1A and melanoma: Recent reports indicate melatonin, as a promoter of mitochondrial biogenesis,77 along with resveratrol, that induced PGC‐1α and mtTFA expression,34 berberine (a natural AMPK activator), that stimulates PGC‐1α and NRF‐2 in neuronal cells,79 and rotenone, an inhibitor of Complex I.80Moreover, necdin (a melanoma antigen) prevents mitochondria‐associated neurodegeneration by binding to PGC‐1α and suppressing its proteolytic degradation in the ubiquitin‐proteasomal system.81, 82