TREM1 and viral infectious disease: Additionally, the triggering receptor expressed on myeloid cells (TREM)-1 ligand is expressed on platelets and has been shown to induce neutrophil activation, and platelets enhance the neutrophil respiratory burst and release of IL-8 in a TREM-1-specific manner in the presence of LPS.43The TREM-1 receptor is an important receptor in the innate immune response as well as in severe sepsis where it amplifies the immune response to microbial products.44TREM-1 has also been shown to contribute to neutrophil activation in viral infections.45