Changes in DNA methylation were associate to specific obesity-related traits, revealing 76 BMI-related sites, 164 waist circumference-related and 8 BMI change-related sites which included already reported ones (HIF3A, CPT1A, ABCG1) and new candidates (e.g., LGALS3BP, KDM2B, PBX1, BBS2) (Fig. 1, lower panel) which were also affected in adipose tissue and involved in lipid metabolism and immune response/cytokine signaling (Demerath et al. 2015). This evidence concerns the gene CPT1A and obesity due to melanocortin 4 receptor deficiency.