miR-155 expression in NAFLD is dysregulated by the transcription factors C/EBP-α, C/EBP-β, PPAR-γ and LXRα (Virtue et al. 2017; Wang et al. 2016) and acts as a central node coordinating FGF21-mediated effects on liver metabolism (see below; Hochreuter et al. 2019). This evidence concerns the gene FGF21 and metabolic dysfunction-associated steatotic liver disease.