CPT1A and obesity due to melanocortin 4 receptor deficiency: The methylation loci were linked to genes involved in lipid and lipoprotein metabolism, substrate transport and inflammatory pathways (e.g., ABGG1, LPIN1, HOXA5, LMNA, CPT1A, SOCS3, SREBF1, PHGDH, NFKB, MAPK, TAK1, IRAK2 and TRAF6) (Fig. 1, lower panel) and that disturbances in DNA methylation predict development of obesity-related disorders like T2D.