ABCA4 and retinal disorder: Patients with the p.(Gly1961Glu) allele exhibit milder diseaseexpression (Burke et al., 2012; Celia et al., 2009), although not in theoverall rate of disease progression but in a distinct phenotypic pattern that,interestingly, overlaps with patients harboring the p.(Asn1868Ile) allele.ABCA4-associated retinopathy invariably begins as amaculopathy with an enlarging lesion of outer retinal atrophy and accumulationof yellow foci, or flecks, at the level of the RPE.