Most ABCA4-associated retinopathy patients exhibit aspatially homogenous and localized increase in RPE lipofuscin because of ABCA4dysfunction (Cideciyan et al., 2004).Augmented RPE lipofuscin confers a Vermillion hue to the fundus under whitelight imaging and can obstruct fluorescence emanating from the underlyingchoroid in during fluorescein angiograms (FA) giving rise to the distinct“dark” or “silent” choroid in up to 62% of patients(Anmarkrud, 1979; Ernest and Krill, 1966; Fish et al., 1981). This evidence concerns the gene ABCA4 and retinal disorder.