In comparison with a perfect gender balance (50%/50%)observed in 284 bi-allelic ABCA4-associated retinopathy probandsnot carrying presumed hypomorphic alleles, this was statistically significant(p = 0.018) (E. Runhart, M. Khan, F.P.M. Cremers, C-M.Dhaenens, unpublished data). Here, ABCA4 is linked to retinal disorder.