Here, we report the characterization of a series of phenotypic FSHD-like mouse models varying in severity from mild to severe, generated using the FLExD conditional DUX4-fl transgenic mouse line crossed with ACTA1-MCM TMX-inducible mice and identify important considerations for using these models. The gene discussed is ACTA1; the disease is facioscapulohumeral muscular dystrophy.