The potential causal relationship between the loss of TDP2 and the oncogenesis is suggested by TCGA database, which shows that homozygous deep deletion of the TDP2 gene is seen in 0.4% and 0.8% of the cancers arising in the breast and prostate tissues, respectively, but not in other cancer types (Sasanuma et al., 2018). The gene discussed is TDP2; the disease is cancer.