From the data mentioned above, CDK4 was found to have a crucial part in controlling the proliferation of glioma cell, to corroborate this, tried to inhibit CDK4 activity using three selective inhibitors abemaciclib, palbociclib and ribociclib and assessed growth inhibition in three human glioma cell lines: A172, U87 and U251. Here, CDK4 is linked to central nervous system cancer.