As shown in Table 2, tumor size, female sex [odds ratio (OR) 1.547; 95% confidence interval (CI) 1.131–2.116; P = 0.006], submucosal invasion (OR 3.836; 95% CI 2.682–5.486; P < 0.001), Poorly-D (OR 2.790; 95% CI 1.743–4.465, P < 0.001), mixed type (OR 2.945; 95% CI 2.039–4.253, P < 0.001), and SRC (OR 2.015; 95% CI 1.164–3.488, P = 0.012) were independent risk factors for LNM. The gene discussed is SRC; the disease is neoplasm.