Circadian clock mal-adjustment contributes to the pathology of various disorders, including insomnia (Flynn-Evans et al., 2017), aging (Tevy et al., 2013), cancer (Stevens, 2009), metabolic syndromes (Bray and Young, 2008), immune system imbalance (Deng et al., 2018), and cardiovascular diseases (Nonaka et al., 2001; Young et al., 2014). The gene discussed is CLOCK; the disease is metabolic syndrome.