As the participation of sBCMA in SLE has been poorly explored despite the relevant role of the BAFF/APRIL system in this disease, the main aim of this study was to analyse the profiles of the B cell factor sBCMA and its ligands sBAFF and sAPRIL in Mexican SLE patients to evaluate the clinical relevance of these molecules. The gene discussed is TNFSF13B; the disease is systemic lupus erythematosus.