When the population was stratified based on obesity status, both the plasma ANGPTL6 and MPO levels were significantly higher in obese participants (ANGPTL6 level: 33.19 ± 11.89 ng/mL and MPO level: 77.29 ± 25.22 ng/mL) than in non-obese controls (ANGPTL6 level: 29.58 ± 8.4 ng/mL and MPO level: 70.48 ± 21.76 ng/mL) (Fig. 1c,d). This evidence concerns the gene ANGPTL6 and obesity due to melanocortin 4 receptor deficiency.