In patients with T2D, both the plasma ANGPTL6 and MPO levels were significantly higher in obese participants than in non-obese participants (ANGPTL6 level: 36.86 ± 11.55 ng/mL vs. 29.05 ± 8.08 ng/mL; P value = 0.003 and MPO level: 75.28 ± 25.94 ng/mL vs. 65.71 ± 15.64 ng/mL; P value = 0.042) (Fig. 2a,b). Here, MPO is linked to type 2 diabetes mellitus.