VAV1 and cancer: Several recent studies have indicated that mutations in various domains of the Vav1 protein are present in human cancers such as adult T-cell leukemia/lymphoma (Kataoka et al, 2015), lung adenocarcinoma and squamous cell carcinomas (Campbell et al, 2016), and peripheral T-cell lymphomas (Abate, da Silva-Almeida et al, 2017).