PDCD1 and neoplasm: For the T-treated group (30 min sampling time point), secretagogin, a tumor marker (Birkenkamp-Demtröder et al. 2005) is up-regulated, while programmed cell death 1 and death effector domain-containing 1, genes involved in apoptosis, are down-regulated (Inohara et al. 1997; Sharpe et al. 2007).