Adjustments were made for categorized initial CD4 counts (< 200 CD4, 200-499, and > 499 CD4 per mm3), CD8 counts (< 643 (first quartile), > = 643 CD8 per mm3), age, time period (1992-1995 (pre-Highly Active Antiretroviral Treatment (HAART) and pre-fungal culture), 1996-2002 (post-HAART and post-fungal culture and pre-ambisome), and 2003-2008 (post-ambisome)), ARV treatment, confirmed histoplasmosis, histoplasmosis treatment (deoxycholate/liposomal amphotericin B and/or itraconazole), confirmed tuberculosis, tuberculosis treatment. The gene discussed is CD8A; the disease is histoplasmosis.