To confirm the anti-tumor effect, we examined the inhibitory effect of Formo on osimertinib sensitive cells, HCC827 (EGFR Del E746-A750), H3255 (EGFR L858R), and H1975 (EGFR L858R/T790M), and osimertinib resistant cells A549 (EGFR WT), H1299 (EGFR WT), and HCC827 OR (osimertinib acquired resistant). This evidence concerns the gene EGFR and neoplasm.