When non-small cell lung cancer (NSCLC) cells were in a normoxia state, overexpression of YTHDF1 promoted tumor cells proliferation and xenograft tumor formation by augmenting the translations of m6A-marked CDK2, CDK4, and cyclinD1, three key regulators in the G0/G1 cell cycle transition. This evidence concerns the gene CDK4 and non-small cell lung carcinoma.