However, Hou et al. found that HIF2α-mediated hypoxia abrogated YTHDF2 expression in HCC cells, and that YTHDF2 deficiency facilitated inflammation, vasculature reconstruction, and metastasis through decreasing the degradation of m6A-marked interleukin-11 (IL-11) and serpin family E member 2 (SERPINE2) mRNAs which were two crucial factors in the processes of inflammation-induced malignancy and vascular remodeling [43]. This evidence concerns the gene SERPINE2 and hepatocellular carcinoma.