In melanoma, depletion of YTHDF2 accelerated cell proliferation and migration by strikingly upregulating the mRNA levels of three key intrinsic pro-tumorigenic factors, including PD-1 (PDCD1), CXCR4, and SOX10, which was dependent on a reduced m6A-mediated mRNA decay [64]. Here, PDCD1 is linked to melanoma.