In this regard, it is notable that although low expression of Abi1 is associated with increased activation of ERK and Akt pathways in hematopoietic cells from CML patients and the K562 CML cell line, such a converse correlation was not observed in Bcr-Abl-transformed Ba/F3 cells [32]. The gene discussed is AKT1; the disease is chronic myelogenous leukemia, BCR-ABL1 positive.