EIF3A and Splenomegaly: Gross pathology analysis revealed that all the mice injected with p185 control cells developed splenomegaly and hepatomegaly (Table 1 and Fig. 5a, b), whereas no apparent splenomegaly nor hepatomegaly was observed in all mice injected with p185 KO 6.2 cells and 90% of the mice injected with p185 KO 2.3 cells (Table 1 and Fig. 5a, b).