In this regard, it is notable that although low expression of Abi1 is associated with increased activation of ERK and Akt pathways in hematopoietic cells from CML patients and the K562 CML cell line, such a converse correlation was not observed in Bcr-Abl-transformed Ba/F3 cells [32]. This evidence concerns the gene ABI1 and chronic myelogenous leukemia, BCR-ABL1 positive.