MAPT and Alzheimer disease: There was a positive association between CSF sTREM2 and T-tau or P-tau in HC (n = 242) and preclinical AD groups (n = 218) (Fig. 3h–i, Fig. 3k-l), whereas no significant association was found between CSF sTREM2 and Aβ1–42 in HC group (β = 0.056, P = 0.198) (Fig. 3b).