The results of gene expression suggest that DFE could lead to coordinated blockade of SREBP-1/FASN/lipogenesis and the AR/PSA axis in PCa cells; (3) By inhibition of SREBP-1 and FASN expression, DFE reduced the intracellular levels of fatty acids and lipid droplet accumulation in PCa; and (4) DFE led to caspase-dependent apoptosis in PCa cells in vitro as well as in mouse xenograft CRPC C4-2 tumors in vivo. Here, KLK3 is linked to posterior cortical atrophy.