In a murine model of MPM, the abscopal effect can be induced by local RT and enhanced by immune-suppressive CTLA-4 blockade as infiltrated T-cells, both in primary and secondary tumor sites, are predominantly composed by anti-tumor cytotoxic CD8+ T-cells, while immunosuppressive regulatory T-cell (Tregs) are reduced [64]. The gene discussed is CTLA4; the disease is neoplasm.