Examples include NET-associated MPO and proteinase 3 (PR3) enzymes as major autoantigenic targets of anti-neutrophil cytoplasmic antibody (ANCA)-associated vasculitis (AAV); NET-derived extracellular nucleic acids and dsDNA as the targets of SLE autoantibodies; citrullinated proteins namely citrullinated histones as neoepitopes for anti-citrullinated protein antibodies (ACPA) in RA [16,17,18]. The gene discussed is PRTN3; the disease is rheumatoid arthritis.