These results are consistent with recent findings that impairments in DNA repair and accumulation of lethal DNA DSBs induced by tyrosine kinase inhibitors sensitize quiescent and proliferative acute myeloid leukemia stem cells to PARP inhibitors olaparib and BMN673 [33], indicating synthetic lethality, a biological phenomenon wherein cell death is induced more efficiently by the simultaneous loss of function of multiple molecular targets or genes compared with the loss of function of a single gene [34]. Here, PARP1 is linked to acute myeloid leukemia.