PARP1 and neoplasm: Similarly, treatment with pan-kinase inhibitors or selective RTKi, namely HS10241, with the PARPi fluzoparib synergistically suppressed tumor growth in multiple cancer types both in vitro and in vivo [32], which is consistent with our findings indicating that PDAC cancer stem cells were more sensitive to the FGFR1 inhibitor PD173074 in the absence of PARP1, in vivo (Figure 6).