Moreover, our findings are particularly relevant when viewed in the context of recently published work indicating that aberrant FGFR1 expression in the tumor vascular niche was implicated in the transformation of indolent cancer cells into chemoresistant cancer stem cells and that FGFR1+ cells were associated with the engraftment of chemoresistant cancer stem cells [29]. The gene discussed is FGFR1; the disease is cancer.