By stimulating the overexpression of anti-apoptotic proteins (Bcl-2/Bcl-xL), downregulating pro-apoptotic Bax, Bcl-Xs and Bak or blocking tumor necrosis factor (TNF)-related apoptosis-inducing ligand (TRAIL)-induced apoptosis and formation of the death-inducing signaling complex with death receptors DR4 and DR5 [5], cytosolic Hsp70 promotes tumor cell survival, protects against apoptosis and promotes tumor progression [6]. Here, TNF is linked to neoplasm.