ACHE and early-onset autosomal dominant Alzheimer disease: M. pulegium EO was also found as the most active inhibitor of BuChE; since this enzyme increases in patients′ brains as the Alzheimer′s disease (AD) progresses, this result on the BuChE inhibiting activity is important, as this cholinesterase may be a better target for the AD therapy compared to AChE, especially in the late stages of the disorder [92].