Tumor necrosis factor receptor-associated factors (TRAF) are a class of multi-functional intracellular signaling adaptor proteins that activate NF-κB through miRs such as miR-146a/b, which inhibits TRAF6 and interleukin-1 receptor-associated kinase (IRAK1) in breast cancer cells [133]. The gene discussed is IRAK1; the disease is breast carcinoma.