An elegant example is presented by Shen et al. who have shown that hypoxia in the TME enhances the association of epidermal growth factor receptor (EGFR) with AGO2 to elevate AGO2-tyrosine393 phosphorylation, which reduces binding of Dicer to AGO2 and inhibits processing of tumor suppressor miR from pre-miRs to mature miRs [91]. The gene discussed is EGFR; the disease is neoplasm.