It was demonstrated that high-density lipoprotein (HDL)-mediated transfer of miR-223 inhibited intercellular adhesion molecule 1 (ICAM1) expression in endothelial cells [57] and we demonstrated that breast tumor-derived non-exosomal LDL-miR-375 was taken up by tumor-associated macrophages via CD36 [10]. The gene discussed is ICAM1; the disease is neoplasm.