CDK4 and melanoma: As per the filtering steps detailed in Figure 1A, 14,048 high-quality variants remained from WES data of eight patients with multiple primary melanomas (MPM), which were negative for all the susceptibility genes for melanoma (CDKN2A, CDK4, MITF, BAP1) and telomere maintenance complex genes such as Telomerase Reverse Transcriptase (TERT), Protection of Telomeres 1 (POT1), Shelterin Complex Subunit and Telomerase Recruitment Factor (ACD) and Telomeric repeat-binding factor 2-interacting protein 1 (TERF2IP).