In our previous study, (−)-9′-O-(α-l-rhamnopyranosyl)lyoniresinol (3), a lignan with rhamnose, induced apoptosis in A2780 human ovarian carcinoma cells through the induction of the extrinsic apoptotic signaling pathway via the activation of caspase-8. This evidence concerns the gene CASP8 and ovarian carcinoma.