PHB1 and infection: PHB1, the other highly homologous PHB, is reported to be involved in EV-A71 infection [24]; thus, it was necessary to rule out the possibility of PHB1 downregulation along with PHB2 knockdown and subsequent PHB upregulation due to EV-A71 infection, and we did not observe down- or upregulation of PHB1 after PHB2 knockdown and EV-A71 infection (Figure 3C).