Weak stimulation by commensal bacteria and fungi causes sparse production of CCL20 from the epidermal keratinocytes, resulting in skewed distribution of CCR6-positive, IL-17-producing cells in the never-lesional skin of psoriasis patients (NLP) over IFNγ-producing cells, which prepare conditions for psoriasis eruption when appropriate insults, such as bacterial or viral infection, or trauma occurs. The gene discussed is IFNG; the disease is psoriasis.