The authors downregulated PLCε expression with PLCε siRNA in esophageal cancer cells and for the first time, they demonstrated that PLCε reduction in esophageal cancer cell lines inhibited cell migration and invasion through PLCε mediated downregulation of PKCα and Nuclear Factor kappa-light-chain-enhancer of activated B cells (NF-κB) [113]. The gene discussed is PLCE1; the disease is esophageal cancer.