For example, PLCβ in neuroendocrine tumors and hematopoietic malignancies [58,59,60,61], PLCγ in breast cancer, colon carcinoma [62,63], lymphocytic leukemia and angiosarcoma [64], PLCδ in esophageal squamous cell carcinoma (ESCC) [65], and PLCε in gastric cancer [66] and colorectal cancer [67]. This evidence concerns the gene PLCE1 and colorectal cancer.