HSPG2 and cancer: Activated PLC isozymes are interconnected with several pathways, such as the PI3K/protein kinase B (PKB/Akt)/mammalian target of rapamycin (mTOR) (PI3K/Akt/mTOR) pathway [76], RAS/rapidly accelerated fibrosarcoma (RAF)/mitogen activated protein kinase (MAPK)/extracellular signal-related kinase (ERK) pathway [77], and the Janus kinase (JAK)/signal transducer and activator of transcription (STAT) [78] pathway that are major regulators of cell growth and proliferation in cancer cells (Figure 3).