SRSF1 and cardiac hypertrophy: In a mouse model of cardiac hypertrophy, the level of PTBP1 expression, as well as epithelial splicing regulatory proteins (ESRP1) and SF2/ASF splicing factors, have been observed to be significantly altered [148], suggesting that the imbalance amount of these splicing factors may lead to a disequilibrium in the expression of tissue-specific regulated genes.