In addition, the CFTR panels in general use during the past two decades have had insufficient CF-causing variants to allow the detection of minority populations in many regions where uncommon CF-causing variants occur such as M1101K (c.3302T>A), found in Hutterite populations [43], and H199Y (c.595C>T) or S492F (c.1475C>T) seen in Hispanic populations [44]. Here, CFTR is linked to cystic fibrosis.