After the initial stress in the cancer microenvironment is sensed by eukaryotic initiation factor (eIF)-2α kinases, such as general control nonderepressible-2, heme-regulated inhibitor, protein kinase R (PKR), and PKR-like endoplasmic reticulum kinase (PERK), SG formation is triggered [30]. The gene discussed is EIF2AK2; the disease is cancer.