PTEN and cancer: For these gene-gene regulations, the most important ones for promoting cancer OXPHOS state are PI3K->mTOR, HIF-1->PDK, Akt->cMyc, mTOR->HIF-1, AMPK-|NOX, cMyc->HIF-1, HIF-1-|AMPK, and Akt->mTOR, whereas the most important ones for promoting the cancer glycolysis state are VEGF->SOD, SOD->p53, HIF-1->NOX, p53-|PDK, p53-|HIF-1, PTEN-|HIF-1, p53->PTEN, mTOR->HIF-1, PTEN->p53, AMPK-|mTOR, and HIF-1-|AMPK.