It also stimulates collagen production and upregulates extracellular matrix genes [21] and is reported to inhibit phosphorylation of ERK1/2, and p38-MAPK kinases.[22] EFEMP1 encodes glycoproteins composing the extracellular matrix component.[23] It also regulate apoptosis of carcinoma cells mediated by SEMA3B,[24] which solely induces apoptosis of tumor cells and is therefore a known tumor suppressor [25,26]. This evidence concerns the gene EFEMP1 and neoplasm.