Panels B, E, and H depict hypoxia in the tumor region (blue corresponds to a depletion of nutrients) while Panels A, D, and G depict the progression of sprouting in the ABM in response to the VEGF field, shown in Panels C, F, and I. Second, the transition from avascular to vascular tumor growth is captured by characterizing the depletion of nutrients in the tumor microenvironment and the delivery of nutrients by vessels that have anastomosed and the corresponding increase in tumor cell proliferation. Here, VEGFA is linked to neoplasm.