In macrophage-derived foam cells, Zhao et al. showed that TRPV1 agonists could upregulate the expression of ABCA1 and ABCG1 in macrophages by regulating liver X receptor α-(LXRα-)-dependent transcription, which could promote the outflow of cholesterol from macrophages, thus delaying the development of atherosclerosis [27]. Here, TRPV1 is linked to atherosclerosis.