Second, researches, such as 123I-MIBG imaging involving therapy-resistant hypertension patients before and after catheter-based renal sympathetic denervation or kidney autotransplantation (Dobrowolski et al. 2015, 2018), have proven the uptake of MIBG into kidney irrelevant to sympathetic nerve activity in the kidney, presumably due to its non-specific uptake via OCT2 or other transporters. The gene discussed is SLC22A2; the disease is hypertensive disorder.