OAS1 and early-onset autosomal dominant Alzheimer disease: Interestingly, we identified three colocalizations between Alzheimer’s disease loci and eQTLs regulating OAS1 gene expression, all of which were identified in stimulated states, suggesting that this association is only active in certain environmental conditions (Fig. 2 and Supplementary Figs 8 and 9), in particular those designed to model monocyte/macrophage priming or more chronic inflammation.