If we consider a sub-network of genes expressed by amyloid-responsive microglia that contains these four novel putative risk genes with the established GWAS loci TREM2, ABI3, CD33, INPP5D, SPI1/PU.1, MS4A6D and GAL3ST4 present in Fig. 1, this sub-network is not highly connected in an innate immune gene network associated with tauopathy (Supplementary Fig. 2), suggesting this sub-network is expressed by microglia that are more responsive to amyloid deposition than other pathological features. This evidence concerns the gene CD33 and tauopathy.