Zhang et al. identified an Alzheimer’s disease-relevant network centred on TYROBP and TREM2, which contained ITGAM/CD11b and LAPTM5 (Zhang et al., 2013), and we described a human microglial network containing LAPTM5, ITGAM/CD11b and LILRB4 (Forabosco et al., 2013). Here, TYROBP is linked to early-onset autosomal dominant Alzheimer disease.