When the entire module of innate immune genes expressed by tauopathy-responsive microglia (2299 genes) was considered there was a modest significant enrichment, P = 1.74 × 10−2, suggesting that a proportion of genes associated with Alzheimer’s disease through multiple SNPs are microglial genes that have mouse orthologues, but are expressed by microglia that are less responsive to tau pathology compared to Aβ deposition. The gene discussed is MAPT; the disease is early-onset autosomal dominant Alzheimer disease.