Cross referencing our network with the data from the ROS/MAP project (Bennett et al., 2012a, b; De Jager et al., 2018), revealed that LAPTM5, ITGAM/CD11b and LILRB4 clustered together with many of the GWAS risk genes for Alzheimer’s disease (Supplementary Fig. 7; Fisher’s Exact test Bonferroni corrected P = 1.34 × 10−13 showing a significant overlap between the genes in the mouse amyloid-associated module and human genes in the ROS/MAP module associated with Alzheimer’s disease). Here, LILRB4 is linked to early-onset autosomal dominant Alzheimer disease.