LAPTM5 and early-onset autosomal dominant Alzheimer disease: Interestingly, SPI1/PU.1, the myeloid cell transcription factor and a newly discovered GWAS risk gene (Huang et al., 2017) was also in the same ROS/MAP module as LAPTM5, ITGAM/CD11b and LILRB4. We confirmed these module memberships in the BRAINEAC data for non-Alzheimer’s disease control human brains generated in our own lab (Ramasamy et al., 2014).