TREM2 and early-onset autosomal dominant Alzheimer disease: Interestingly, we found that SPI1/PU.1 binds to the regulatory regions of Laptm5 and Itgam/CD11b, as well as established Alzheimer’s disease risk gene orthologues Trem2, Abi3, Inpp5d, Ms4a6d and Spi1/PU.1 itself, by searching data from a chromatin immunoprecipitation experiment against SPI1/PU.1 in mouse microglial-like BV-2 cells (Satoh et al., 2014).