ITGAM/CD11b was highlighted in recent genetic and functional analyses as likely being important for the progression of Alzheimer’s disease, whose expression was driven by SPI1/PU.1, and related to amyloid deposition in mice and humans (Zhang et al., 2013; Hong et al., 2016; Kamphuis et al., 2016; Olmos-Alonso et al., 2016; Huang et al., 2017; Nam et al., 2018). Here, ITGAM is linked to early-onset autosomal dominant Alzheimer disease.