PIK3C3 and infection: Consistent with the key role for CD46 in early autophagy induction by vaccinal/attenuated MeV, virulent/clinical MeV strains that are independent of CD46 for infection do not trigger any signs of early autophagic activity, indicating that the CD46-Cyt-1-GOPC-VPS34-BECN1 complex axis constitutes the sole pathway for early autophagy induction by vaccinal/attenuated strains of MeV [71].