As CD46 is also a receptor for various other pathogens such as the human herpes virus HHV-6, the BVDV pestivirus and adenoviruses B and D, the CD46-Cyt-1-GOPC-VPS34-BECN1 complex axis is likely to also trigger autophagy during infection by those microbes [73]. Here, PIK3C3 is linked to infection.