It has been reported that mitophagy is significantly impaired in neurodegenerative disorders such as Alzheimer’s disease (AD) and Ataxia telangiectasia (A-T), while mitophagy stimulation induces beneficial effect including an increase in cognition and an extended lifespan in a NIX- or PINK1 and Parkin-dependent manner (Fang et al., 2016, 2019). Here, PINK1 is linked to early-onset autosomal dominant Alzheimer disease.