In several human cancer types, including hematological malignancies, lung, breast, gastric, pancreatic, and liver cancer, the epigenetic silencing of BNIP3 expression is reported to correlate with invasiveness and metastasis (Okami et al., 2004; Koop et al., 2009; Chourasia et al., 2015). The gene discussed is BNIP3; the disease is cancer.