The anti‐inflammatory effect of PD has been confirmed in mice with nonalcoholic steatohepatitis,[qv: 23] and hepatic macrophages are known to play a central role in initiating and perpetuating inflammation which mediated the pathogenesis of hepatic fibrosis.[qv: 24] Thus, we explored whether PD‐MC could reduce the inflammatory reaction in LPS‐activated RAW cells and primary hepatic macrophages isolated from fibrotic mice by measuring the proinflammatory cytokines (IL‐1β, IL‐6, and TNF‐α). This evidence concerns the gene IL6 and metabolic dysfunction-associated steatohepatitis.