TNF and neoplasm: As a consequence, by tumor immunotherapy in combination with PTT, these contributors together almost completely inhibited the tumor growth accompanied with enhanced anti‐tumor immune responses and elevated expression levels of proinflammatory cytokines (e.g., IFN‐γ, TNF‐α, IL‐6, IL‐12p40), resulting in significantly suppressed primary tumor growth as well as lung metastasis in CT26 tumor bearing mice.