MMP9 and neoplasm: “Smart” biological response materials sensitive to intracellular signals of cancer cells are attractive therapeutic platforms for the development of the next generation of personalized drugs.[[qv: 16]] It has been reported that combretastatin A4 nanodrug boosted tumor‐selective release of Doxorubicin prodrug via inducing MMP9 amplification.[[qv: 17]] Herein, we utilized the 8P4 as the most effective drug‐loading nanodelivery system to deliver THZ1/JQ1 into PDAC cells.