SMAD3 and cancer: One example is the transcription factor SMAD3, which represents a signaling effector of transforming growth factor‐β (TGF‐β) signaling.[[qv: 10]] SMAD3 mediates transcription responsible for creating drug‐tolerant cancer stem‐like cells that facilitate metastatic progression.[[qv: 11]] These findings suggest that transcriptional‐amplified SMAD3 may become a biomarker per se for THZ1/JQ1‐sensitive PDAC.