Consequently, cancer cells are sensitive to reactive oxygen species‐induced lysosomal membrane permeabilization (LMP).[[qv: 18]] Therefore, based on these facts, we propose that during internalization the J/T@8P4 NPs accumulated in the fragile lysosome of PDAC, and then the breakdown of 8P4 NPs impaired the lysosomes leading to the LMP and release of THZ1/JQ1 for enhanced therapeutic efficacy in PDAC cells. Here, PDLIM7 is linked to cancer.