Analyses were performed using a two sample MR, and after multiple testing correction, a causal role of DNAm on T2D (at p < 1.39 × 10−8) was identified at CpG sites in cg04198914 (HNF1B), cg03864215 (KCNJ11), cg23956648 (IGF2BP2), and cg25064352 (WFS1) [47•], as well as at cg15453836 (PEAK1) and cg01883759 (JAZF1) [47•]. Here, HNF1B is linked to type 2 diabetes mellitus.