KCNQ1 and type 2 diabetes mellitus: However, recent genetic studies of DNAm using peripheral blood have provided less evidence that DNAm is mediating the effect between known T2D-SNPs and T2D risk [46, 47•], with the exception of methylation at the T2D candidate loci KCNJ11, WFS1 [47•], and KCNQ1 [46].