ABCG1 and type 2 diabetes mellitus: However, there has been little overlap between CpG sites identified in EWAS of these tissues and EWAS of blood, except for at ABCG1, which was hypermethylated in blood and in adipose tissue of T2D cases [54], and MSI2, which was hypomethylated in blood and in pancreatic islets of T2D donors [58].