To further support a mechanistic role of methylation at ABCG1 and PHOSPHO1 on T2D, Dayeh et al. compared the association at these sites using target tissues for T2D, identifying consistency in the direction of effect between blood and adipose tissue for ABCG1, and between blood and skeletal muscle for PHOSPHO1 [54]. The gene discussed is PHOSPHO1; the disease is type 2 diabetes mellitus.