Forkhead box class O6 (FOXO6) is a member of the FOXO family that can regulate diabetes-induced OS, and the suppression of FOXO6 protects ARPE-19 cells from HG-induced OS and apoptosis, which is in part mediated by the activation of the Akt/Nrf2 pathway [132]. Here, FOXO6 is linked to diabetes mellitus.