NFE2L2 and neoplasm: Further mechanistic insights into Nrf1α−/−-derived malignance discovered that significantly decreased expression of the tumor repressor PTEN leads to the reversed activation of its downstream AKT oncogenic signaling, as also accompanied by augmented expression of COX-2 and other inflammatory cytokines in Nrf1α−/−, but not Nrf2−/−, cells [23].