NRF1 and hepatocellular carcinoma: Insights into the pathobiological mechanisms of Nrf1-deficient hepatoma have discovered that ubiquitin-mediated proteasomal degradation of β-catenin is seriously impaired by silencing of Nrf1 so that it is accumulated and translocated into the nucleus, leading to Wnt/β-catenin-mediated transcriptional activation of target genes.