Further comparative analysis unraveled that silencing of Nrf1 led to obvious down-expression of 27 genes critical for cancer cell adhesion and ECM remodeling, of which 8 genes (i.e., EGFR, CAV1, CAV2, MET, LRRF1P1, SDC1, TNS1, and CCDC77) were almost unaltered by Nrf1α−/−, but with an exception of 3 genes (IGF1R, TPBG, and NEDD9) that were strikingly upregulated by this knockout of Nrf1α−/− (, and ). The gene discussed is NRF1; the disease is cancer.