Clearly, the aberrant (and/or mutant) activation of Keap1-Nrf2 and Wnt/β-catenin signaling cascades is a genetic predisposition to hepatocellular carcinoma, in which the CTNNB1 mutation appeared to occur earlier during child liver carcinogenesis, whereas the NFE2L2 mutation was acquired later [40–42]. The gene discussed is NFE2L2; the disease is hepatocellular carcinoma.