Thereby, it is postulated that though TCF4 was bona fide down-expressed in Nrf1-silenced cells, the LEF/TCF family factors are also functionally redundant in the human Wnt/β-catenin signaling activation stimulated by deficiency of Nrf1, as identified by Hrckulak et al. [65] that TCF4 is dispensable for the Wnt signaling in human cancer cells. The gene discussed is HNF4A; the disease is cancer.