In the parallel xenograft experiments, the shNrf1-driven tumor appears to be a little more severe than the case of Nrf1α−/− (with aberrant accumulation of Nrf2), by comparison of subcutaneous tumorigenesis in speeds and sizes, as accompanied by cancer metastasis and cachexia syndromes (compare this work with our previous [36]). Here, NFE2L2 is linked to cancer.