Obesity-related indicators included short chain fatty acids (acetic acid, butyric acid, propionic acid and valeric acid), genes of epididymal adipose tissue (AMPK-α, HSL, ACC, FAS, PPAR-γ, and C/EBP-α), hepatic parameters (TG, CAT, SOD, GSH-Px, GSH, MDA, ALT, and AST) and blood lipids (TG, TC, HDL-C, and LDL-C). This evidence concerns the gene SOD1 and obesity due to melanocortin 4 receptor deficiency.